USP25m is the muscle Musculoskeletal Health isoform of the deubiquitinating (DUB) enzyme USP25.Similarly to most DUBs, data on USP25 regulation and substrate recognition is scarce.In silico analysis predicted three ubiquitin binding domains (UBDs) at the N-terminus: one ubiquitin-associated domain (UBA) and two ubiquitin-interacting motifs (UIMs),
A British general adult psychiatrist born and trained in the UK, who also considers himself Pakistani, had Dollhouses the opportunity to spend 2 weeks running a psychiatric clinic in a remote hospital in the Punjab province of Pakistan.In this article he offers some reflections on the unexpected culture shock he felt, on the hospital system, the pa
Abstract Background To combat coronavirus disease 2019 (COVID-19), booster vaccination strategies are important.However, the optimal administration of booster vaccine platforms remains unclear.Herein, we aimed to assess the benefits and harms of three or four heterologous versus homologous booster regimens.Methods From November 3 2022 to December 2
With an increasing focus on sustainable development and the reuse of disused infrastructure, there is a pressing need for effective decision-making methods.This study explored the use of the PROMETHEE method within a collaborative decision-making framework Laces to assess the adaptive reuse options for a disused railway in Sicily, Italy.Using a par